Institute of Graduate Education

Academic Members

Prof. Yusuf  Sarıoğlu

Prof.
Yusuf Sarıoğlu

Tıbbi Farmakoloji

Dr. Yusuf Sarioglu graduated from Hacettepe University Faculty of Pharmacy in 1973. He graduated from Hacettepe University Faculty of Medicine, Department of Internal Medicine, with Masters degree in Department of Medical Pharmacology in 1978 and doctorate in 1982. Dr. Yusuf SARIOĞLU became Associate Professor in the Department of Medical Pharmacology in Cumhuriyet University Faculty of Medicine, Department of Internal Medicine, and later became Professor in 1992. In 1992, he continued his research at Kings College of Medicine, London. Dr. Yusuf Sarioglu was head of Medical Pharmacology departments at Cumhuriyet University and Gazi University. He was also a member of Senate, director of the Institute of Health Sciences, provincial coordinator of Measuring, Selection and Placement Center (OSYM) and open education system at Cumhuriyet University . He was editor of Medical Pharmacology of Journal of Medical Sciences of Turkey and a member of Ministry of Health Pharmaceuticals and Medical Devices Agency Original Drug Licensing Commission. He served as a member of the Ethics Committee of the Faculty of Medicine of the University, was a member of the Ethics Committee at the Ankara Numune Hospital and Gazi University Faculty of Medicine. In the International Journals covered by the SCI, he has 725 citations to 96 published research articles (h-index is 15, h-10-index is 29). He also has many articles at national and international conferences. He is currently is a faculty member and Head of Department of Medical Pharmacology at the Faculty of Medicine of İstinye University.

Araştırma Alanları

  • Nitric oxide
  • hyrogen sulphide
  • erectile disfunction
  • neuropharmacology
  • Nanc Nervous system

Çalışma Alanları

  • Sağlık Bilimleri Temel Alanı
  • Tıbbi Farmakoloji
  • The effects of different vasovasostomy techniques on motility of vas deferens (vas motility following vasovasostomy), 2023
  • Enhancing effect of nicotine on electrical field stimulation elicited contractile responses in isolated rabbit bladder straight muscle; the role of cannabinoid and vanilloid receptors, 2022
  • Effects of epoxygenases on the nonadrenergic noncholinergic relaxant responses induced by electrical field stimulation in rabbit corpus cavernosum, 2019
  • Effects of agmatine on cognitive functions during vascular dementia in biological aging through eNOS and BDNF expression, 2017
  • Changes in cholinergic and nitrergic systems of defunctionalized colons after colostomy in rabbits, 2017
  • Changes in cholinergic and nitrergic systems of defunctionalized colons after colostomy in rabbits, 2017
  • Microwave assisted synthesis and myorelaxant activity of 9 indolyl 1 8 acridinedione derivatives, 2014
  • Effects of chronic low and high dose ethanol intake on the nitrergic relaxations of corpus cavernosum and penile nitric oxide synthase in the rabbit, 2012
  • A Cannabinoid Ligand Anandamide Exacerbates Endotoxin Induced Uveitis in Rabbits, 2011
  • Chronic administration of fluoxetine impairs neurogenic and endothelium dependent relaxation of the rabbit corpus cavernosum smooth muscle, 2011
  • Changes in the neurogenic and endothelium dependent relaxant responses of rabbit corpus cavernosum smooth muscle after cavernous nerve neurotomy, 2010
  • Enhancement effects of nicotine on neurogenic relaxation responses in the corpus cavernosum in rabbits The role of nicotinic acetylcholine receptor subtypes, 2010
  • Investigation of enhancement effects of nicotine on cholinergic neurotransmission in isolated rabbit gastric fundus role of antioxidants, 2010
  • Effect of a Chloride ChannelInhibitor 5 Nitro 2 3 Phenylpropylamino Benzoate on Endothelin 1 InducedVasoconstriction in RabbitBasilar Artery, 2009
  • Condensed 1 4 dihydropyridines with various esters and their calcium channel antagonist activities, 2009
  • Role of nicotinic acetylcholine receptor subtypes on nicotine induced neurogenic contractile response alternation in the rabbit gastric fundus, 2009
  • Functional Characterization of Nonadrenergic Noncholinergic Neurotransmitter Release via Endocannabinoids An in Vitro Study in Rabbit Corpus Cavernosum, 2009
  • Effect of a chloride channel inhibitor 5 nitro 2 3 phenylpropylamino benzoate on endothelin 1 induced vasoconstriction in rabbit basilar artery, 2009
  • Effects of diabetes and elevated glucose on nitrergic relaxations in the isolated duodenum of the rat, 2009
  • Evaluation of myorelaxant activity of 7 substituted hexahydroquinoline derivatives in isolated rabbit gastric fundus, 2008
  • Synthesis and Calcium Modulatory Activity of 3 Alkyloxy carbonyl 4 disubstituted aryl 5 oxo 1 4 5 6 7 8 hexa hydroquinoline Derivatives, 2008
  • The effects of varicocele and its surgical correction on vas deferens motility, 2008
  • Does tourniquet application alter the nitrergic responses of rabbit corpus cavernosum penis, 2008
  • Hydrogen peroxide and antioxidizing enzymes involved in modulation of transient facilitatory effects of nicotine on neurogenic contractile responses in rat gastric fundus, 2008
  • Lack of nitrate tolerance in isosorbid dinitrate and sodium nitroprusside induced relaxation of rabbit internal anal sphincter, 2008
  • Synthesis of 2 Methyl 4 aryl 4 6 7 8 tetrahydro 5 1H quinolone Derivatives and their Effects on Potassium Channels, 2008
  • Nicotine potentiates the nitrergic relaxation responses of rabbit corpus cavernosum tissue via nicotinic acetylcholine receptors, 2007
  • Nicotine potentiates the neurogenic contractile response of rabbit bladder tissue via nicotinic acetylcholine receptors Nitric oxide and prostaglandins have no role in this process, 2007
  • Nicotine Potentiates the Electrical Field Stimulation Evoked Contraction of Non Pregnant Rabbit Myometrium, 2007
  • Enhancement effects of nicotine on neurogenic contractile responses in rabbit gastric fundus, 2007
  • Effects of Varicocele on Electrical Field Stimulation Induced Biphasic Twitch Responses in the Ipsilateral and Contralateral Rat Vasa Deferentia, 2007
  • Torsion Detorsion of the Testis Does Not Modify Responses to Nitric Oxide in Rat Isolated Penile Bulb, 2007
  • Effects of Mexiletine on Electrical Field Stimulation Induced Contractile Responses in the Ipsilateral and Contralateral Vasa Deferentia after Unilateral Testicular Torsion Detorsion, 2006
  • Agmatine facilitates sympathetic neurotransmission in frog myocardium via an action on alfa 2 adrenergic receptors, 2006
  • Reactive oxygen species mediate abnormal contractile response to sympathetic nerve stimulation and noradrenaline in the vas deferens of chronically diabetic rats effects of in vivo treatment with antioxidants, 2005
  • Effects of platelet activating factor on nitrergic transmission in rabbit corpus cavernosum, 2005
  • Effects of Amifostine on Glycerol Pretreated Rabbit Kidneys, 2005
  • EFFECTS OF CANNABINOID RECEPTOR ACTIVATION ON RABBIT BISECTED VAS DEFERENS STRIPS, 2005
  • Enhancement of EFS induced contractions by agmatine in guinea pig gallbladder smooth muscle strips, 2005
  • The effects of melatonin on electrical field stimulation evoked biphasic twitch responses in the ipsilateral and contralateral rat vasa deferentia after unilateral testicular torsion detorsion, 2005
  • Relaxation effects of adrenomedullin in isolated rabbit corpus cavernosum smooth muscle, 2004
  • Investigation of the mechanism of nicotine induced relaxation in rabbit corpus cavernosum in vitro, 2004
  • The evaluation of the effects of renal failure on erectile dysfunction in a rabbit model of chronic renal failure, 2003
  • The effect of chronic renal failure on phosphodiesterase inhibitor induced relaxation responses in rabbit cavernosal strips, 2003
  • Relaxant effect of omeprazole and lansoprazole in guinea pig gallbladder muscle strips in vitro, 2003
  • Gastric smooth muscle contractility changes in the esophageal atresia rat model an in vitro study, 2003
  • Impaired gastric motility in the gastroesophageal reflux rat model an in vitro study, 2003
  • OMEPRAZOLE-INDUCED RELAXATION IN RAT AORTA IS PARTLY DEPENDENT ON ENDOTHELIUM, 2002
  • The Role of K Channels on the Inhibitor Effect of Sevoflurane in Pregnant Rat Myometrium, 2002
  • Effect of chronic renal failure on the purinergic responses of corpus cavernosal smooth muscle in rabbits, 2002
  • Hydrogen potassium ATPase inhibitors induce relaxation on rabbit prostatic strips in vitro, 2002
  • Vasorelaxing properties of some phenylacridine type potassiumchannel openers in isolated rabbit thoracic arteries, 2002
  • OMEPRAZOLE INDUCED RELAXATION IN RAT AORTA IS PARTLYDEPENDENT ON ENDOTHELIUM, 2002
  • Investigation of the Mechanism of Nicotine Induced Relaxationin Guinea Pig Gallbladder, 2002
  • Aging Impairs Nitric Oxide Mediated Relaxant Responses of Rabbit Corporal Smooth Muscle, 2002
  • Effects of the speci c phosphodiesterase inhibitors onalloxan induced diabetic rabbit cavernous tissue in vitro, 2001
  • Inhibitor effect of omeprazole in isolated humanmyometrial smooth muscle, 2001
  • Relaxant effects of some benzothiazolinone derivatives on isolated rabbit corpus cavernosum, 2001
  • Relaxation induced by omeprazole does not change in diabetic rabbit corpus cavernosum, 2001
  • Evidence of relaxant effect of omeprazole in rabbit corpus cavernosum in vitro, 2000
  • Effects of exogenous testosterone on isolated rabbit corpus cavernosum penis, 2000
  • Does Diabetes Mellitus Affect the Progress of Tolerance to Isosorbide Dinitrate ISDN in Corporal Tissue, 2000
  • Effects Of Experimental Obstructive Jaundice On Contractile Responses Of Dog Isolated Blood Vessels Role Of Endothelium And Duration Of Bile Duct Ligation, 2000
  • Corporal reactivity to adenosine and prostaglandin E1 in alloxan induced diabetic rabbit corpus cavernosum and the effect of insulin therapy, 1999
  • The effects of long term oral administration of l arginine on the erectile response of rabbits with alloxan induced diabetes, 1999
  • Effects of chronic unilateral internal pudendal arterial occlusion on reactivity of isolated corpus cavernosum strips from rabbits, 1999
  • Effects of endothelin 1 and calcium channel blockers on contractions in human myometrium A study on myometrial strips from normal and diabetic pregnant women, 1999
  • Tolerance to isosorbide dinitrate in isolated strips of rabbit corpus cavernosum, 1998
  • Effects of nimodipine and isradipine on endothelin 1 induced contraction of pregnant rat myometrium, 1998
  • Effect of endothelin 1 on spontaneous contractions and effects of nimodipine and isradipine on endothelin 1 induced contractions in myometrial strips isolated from normal pregnant and preeclamptic women, 1998
  • Tolerance to isosorbide dinitrate in isolated strips of rabbit corpus cavernosum, 1998
  • Impaired contraction and relaxation in the aorta of streptozotocin diabetic rats, 1998
  • Effect of additional testosterone on purinergic responses in isolated rabbit corpus cavernosum strips, 1998
  • Changes in the nitric oxide system of rat myometrium during midgestation and delivery at term, 1998
  • Inhibitory effects of isradipine on spontaneous and oxytocin and carbachol stimulated contractions of rat myometrium, 1998
  • Effects of deferoxamine and sympathectomy on endothelin 1 induced contraction and acetylcholine Induced relaxation following subarachnoid hemorrhage in carotid artery, 1997
  • Effects of sympathectomy on endothelin 1 and histamine responses of rabbit carotid artery, 1997
  • Effects of castration on adrenergic cholinergic and nonadrenergic noncholinergic responses of isolated corpus cavernosum from rabbit, 1997
  • Vascular smooth muscle reactivity and endothelium derived relaxing factor in experimental obstructive jaundice, 1996
  • Altered endothelium mediated relaxation by sympathectomy in isolated rabbit carotid artery rings, 1995
  • Effects of propofol on vascular smooth muscle function in isolated rat aorta, 1994
  • Selective inhibition of endothelium dependent relaxation by sympathectomy in rabbit carotid artery rings in vitro, 1993
  • Effect of chronic experimental diabetes on vascular smooth muscle function in dog femoral artery, 1993
  • Effect of ketamine on contractile performance of isolated frog myocardium and comparison of ketamine thiopental and droperidol, 1992
  • Changes in human plasma dopamine beta hydroxylase activity after ketamine and halothane anesthesia, 1992
  • An evidence for presynaptic excitatory alpha 2 adrenergic receptors in frog myocardium, 1988
  • H-K ATPase inhibitor, Causes Relaxation of Alloxan- induced Diabetic Rabbit Corpus cavernosum.,
  • Renal Vascular Reactivity in Obstructive Jaundice,
  • Effects of Propofol on the IsolatedVas Deferens of the Rat. Intensive Care Medicine,
  • Vascular Smooth Muscle Reactivity and EDRF in Experimental Obstructive Jaundice,
  • Altered Endothelium-mediated Relaxation in the Isolated Rabbit Carotid Artery Rings after Sympathectomy,
  • The Effect of Insulin And L-Arginine Treatment on Impaired Neurogenic and Endothelium-Dependent Relaxation in Alloxan-Induced Diabetic Rabbit Corpus Cavemosum.,
  • Chronic L-DOPA AdministrationDecreases Relaxation Responses of Corpus Cavernosum Tissue of Rabbit.,
  • Tolerance to Isosorbide Dinitrate (ISDN) in isolated Strips of Rabbit CorpusCavernosum.,
  • The Effects of Insulin and L-Arginine Therapy on the Reactivity of Corporal Smooth Muscle to Adenosine and Prostoglandin E1 in the Alloxan-Induced Diabetic Rabbit Corpus Cavemosum,
  • The Effects of Chloride Channels on Electrical Field Stimulation Mediated NO-Dependent and –Independent Nonadrenergic Noncholinergic Relaxation Responses in Rabbit Corpus Cavernosum.,
  • Agmatine Attenuates Vascular Dementia in Ageing.,
  • Diyabetoloji Birincilik Ödülü, 1992
  • Farmakoloji Bilimi Üçüncülük Ödülü, 1992
  • 100.Yıl Ulusal Tıp Araştırma Yarışması Mansiyon Ödülü ( Beşincilik), 1998
  • 25. Yıl Bilim Ödülü. (Sağlık Bilimleri Alanında), 1999
  • Farmasötik ve Medisinal Kimya İlaç Tasarım ve Geliştirme Araştırma Ödülleri Üçüncülük Ödülü, 2008
  • En İyi Poster Ödülü, 2012
  • Prof.Dr. Reşat Garan Mansiyon Ödülü , 1994
  • 10. Uluslararası Psikofarmakoloji Kongre Ödülü, 2018