Dr. Öğretim Üyesi Esma Nur Okatan 2006 yılında Gazi Üniversitesi Biyoloji Bölümünden birincilikle mezun olduktan sonra lisansüstü eğitimine Ankara Üniversitesi Tıp Fakültesi Biyofizik Anabilim dalında devam etmiştir ve yüksek lisans eğitimi süresince Tübitak tarafından desteklenmiştir (BİDEP 2228-A). 2009'da aynı bölümde araştırma görevlisi olarak atanarak (33-a) doktora eğitimine devam etmiştir. 2015 yılında doktora eğitimini tamamladıktan sonra Sivas Cumhuriyet Üniversitesinde akademik hayatına öğretim üyesi olarak devam etmiştir. Cumhuriyet Üniversitesi Tıp Fakültesi Araştırma Merkezi (Müdür yardımcısı) ve İleri Teknoloji Araştırma ve Uygulama Merkezinde (Western blot sistem sorumlusu) idari görevler almış ve protein analiz sistemlerini (western blot sistemi) hizmet verir duruma getirmiştir. 2015-2020 yılları arasında biri üniversite diğeri ise Türkiye Diyabet Vakfı (2016 En İyi Bilimsel Proje Ödülü kapsamında) tarafından desteklenen iki bireysel projeyi yürütücü olarak tamamlamıştır. In vivo ve in vitro deneysel diyabet/insulin direnci modellerinde araştırmalar gerçekleştirmiş ve diyabetik kardiyomiyopati/kardiyak insulin direncinin altında yatan elektrofizyolojik ve moleküler etkileşimleri incelemiştir. Dr. Öğretim Üyesi Esma Nur Okatan'ın Web of Science’ da taranan ve SSCI kapsamında 18 uluslararası araştırma makalesi bulunmaktadır ve bu makalelerin toplam atıf sayısı 396, h-endeksi 13 ve i10-endeksi 14’dür.
Araştırma Alanları
- Diyabet
- Hücre içi kalsiyum sinyalizasyonu
- Nöroinflamasyon
- Biyoelektrik
Çalışma Alanları
- Sağlık Bilimleri Temel Alanı
- Biyofizik
- Azoramide improves mitochondrial dysfunction in palmitate-induced insulin resistant H9c2 cells, 2019
- The Contribution of Phosphodiesterases to Cardiac Dysfunction in High Carbohydrate Diet-Induced Metabolic Syndrome Rats, 2019
- Interplay Between Cytosolic Free Zn2+ and Mitochondrion Morphological Changes in Rat Ventricular Cardiomyocytes, 2016
- Electrophysiological basis of metabolic syndrome induced cardiac dysfunction title, 2016
- Pioglitazonun Metabolik Sendromlu Sıçan Kalp Fonksiyonuna Etkisinin Elektrofizyolojik Yöntemlerle İncelenmesi, 2015
- Profiling of cardiac β-adrenoceptor subtypes in the cardiac left ventricle of rats with metabolic syndrome: Comparison with streptozotocin-induced diabetic rats, 2015
- High carbohydrate diet induced myocardial remodeling in rats, 2015
- Enhancement of Cellular Antioxidant-Defence Preserves Diastolic Dysfunction via Regulation of Both Diastolic Zn2+and Ca2+and Prevention of RyR2-Leak in Hyperglycemic Cardiomyocytes, 2014
- Improvement of Functional Recovery of Donor Heart Following Cold Static Storage with Doxycycline Cardioplegia, 2014
- ß-Blocker Timolol Prevents Arrhythmogenic Ca2 Release and Normalizes Ca2 and Zn2 Dyshomeostasis in Hyperglycemic Rat Heart, 2013
- Cardioprotective effect of selenium via modulation of cardiac ryanodine receptor calcium release channels in diabetic rat cardiomyocytes through thioredoxin system, 2013
- Doxycycline Ameliorates Vascular Endothelial and Contractile Dysfunction in the Thoracic Aorta of Diabetic Rats, 2011
- Intracellular free zinc during cardiac excitation–contraction cycle: calcium and redox dependencies, 2011
- Cardioprotective effect of propranolol on diabetes-induced altered intracellular Ca2 signaling in rat, 2011
- Age related regulation of excitation contraction coupling in rat heart, 2011
- Selenium restores defective beta-adrenergic receptor response of thoracic aorta in diabetic rats, 2010
- Antioxidants but not Doxycycline Treatments Restore Depressed Beta-Adrenergic Responses of the Heart in Diabetic Rats, 2009
- Omega-3E treatment regulates matrix metalloproteinases and prevents vascular reactivity alterations in diabetic rat aortaThis article is one of a selection of papers published in a special issue on Advances in Cardiovascular Research., 2009
- Antioxidant Treatments Improve Diabetes Induced Endothelium Dependent Vascular Dysfunction, 2009
- Monitoring of intracellular free Zn2+ and Ca2+ changes in cardiomyocytes from metabolic syndrome rats, 2015
- An investigation on the antioxidant activity of azoramide, a promising new anti-diabetic, in palmitate-induced insulin resistance in H9c2 cells,
- Beneficial Effects Of Azoramide On Palmitate-Induced Insulin Resistance In H9c2,
- Azoramidin Anti-Diyabetik Etkisinde İnsülinin Sinerjistik Rolü,
- Mitochondria-directed approaches seem to play important role in the cellular therapy of cardiac dysfunction, 2019
- Roles of oxidant stress and matrix metalloproteinases in endothelium- dependent relaxation of diabetic rat thorasic aorta, 2008
- Matrix metalloproteinases contribute to diabetes induced cardiovascular dysfunction, 2008
- ZINC RELEASE MODULATES CARDIAC RYANODINE RECEPTORS, 2009
- Profiling of cardiac beta-adrenoceptor subtypes in left ventricle from metabolic syndrome rat heart: Comparison with streptozotocin-diabetic rat.,
- Pre-diyabet oluşturulmuş sıçanlarda kardiyomiyositlerin ışık mikroskobunda değerlendirilmesi., 2014
- Yüksek karbonhidrat diyeti etkisinin sıçan kalbi ince-yapı bulguları ile gösterilmesi., 2013
- Doxycycline regulates intracellular zinc in diabetic rat heart via regulation of cellular redox cycle,
- Timolol treatment of diabetic rats improved basal cardiac function and responses to 3 but not 1 and 2 receptors stimulations, 2011
- Depressed Sarcoplasmic Reticulum Activity Underlies Ca2 Dyshomeostasis in A Rat Model of Metabolic Syndrome, 2015
- Intracellular Zn 2 Release Modulates Cardiac Ryanodine Receptor Function and Cellular Activity, 2010
- Beneficial Effect Of Sodium Selenate On Vascular Dysfunction In Diabetic Rats International Societyfor Heart Research, 2007
- Intracellular free Zn2 increase induces marked changes in mitochondrial function and ultrastructure in cardiac cells,
- Intracellular free Zn2 increase induces marked changes in mitochondrial function and ultrastructure in cardiac cells, 2016
- Investigation on the cross talk between 3 Adrenergic receptor and Zn2 signalling in diabetic cardiomyocytes, 2016
- Investigation on the cross talk between 3 Adrenergic receptor and Zn 2 signaling in diabetic cardiomyocytes,
- Intracellular free Zn2 increase induces marked changes in mitochondrial function and ultrastructure in cardiac cells, 2016
- Monitoring of intracellular free Zn2 and Ca2 changes in cardiomyocytes from metabolic syndrome rats, 2015
- Depressed Sarcoplasmic Reticulum Activity Underlies Ca2 Dyshomeostasis in A Rat Model of Metabolic Syndrome, 2015
- Monitoring of intracellular free Zn2 and Ca2 changes in cardiomyocytes from metabolic syndrome rats, 2015
- Depressed Sarcoplasmic Reticulum Activity Underlies Ca2 Dyshomeostasis in A Rat Model of Metabolic Syndrome, 2015
- Alterated Intracellular Calcium Ion Regulation Plays Important Role in High Carbohdyrate Intake Induced Myocardial Remodeling, 2015
- Doxycycline ameliorates diabetes induced vascular dysfunction, 2007
- Diyabetli sıçan damar düz kası A1 Adrenerjik yanıtlarında matriksmetalloproteinazlar ve oksidan stresin rolü,
- Roles of oxidant stress and matrix metalloproteinases in endothelium dependent relaxation of diabetic rats, 2008
- Role of intracellular zinc on phosphorylation level of cardiac ryanodineReceptors in normoglycemic and hyperglycemic rats,
- EFFECTS OF ASTRAGALUS EXTRACT ON OXIDANT ANTIOXIDANT STATUS AND MYOCARDIAL CONTRACTILITY IN STREPTOZOCIN INDUCED DIABETIC RATS, 2009
- Beneficial role of selenium on diabetes induced altered adrenergic receptorresponse of aortic smooth muscle of the rats, 2010
- Oxidative stress plays important role on cardiac ryanodine receptor calciumrelease channels in diabetic rats, 2011
- Oksidatif stresin kardiyak ryanodin reseptörleri üzerine etkisinin diyabetik sıçankalplerinde incelenmesi,
- Cardioprotective effect of sodium selenate or thioredoxin through ryanodinereceptor modulation,
- Investigation of in vitro effect of timolol on sarcoplasmic reticulum functionin streptozotocin induced diabetic rat heart,
- Metabolik sendromlu sıçanlarda kalbin elektriksel ve mekanik aktivitesi üzerine bir çalışma,
- An electrophysiological investigation on cardiac function from ratssupplemented with high carbohydrate diet,
- Yüksek Sükrozla İndüklenen Metabolik Sendromlu Sıçan Kardiyomiyositlerinde Hücre İçi Ca2 Homeostazına Etkili Faktörlerin İncelenmesi,
- Timolol Treatment of Diabetic Rats Improved Basal Cardiac Function and Responses to 3 but not 1 and 2 receptors Stimulations,
- A Comparative Study on Beneficial Effects of Antioxidants on Diabetes induced Cardiac Contractile Dysfunction,
- Increased Oxidative Stress Triggers Marked Intracellular Zinc Elevation in Cardiomyocytes Under Hyperglycemia, 2014
- Hücre İçi Serbest Zn 2 nun Kardiyomiyositlerde Uyarılma Kasılma Çiftlenimindeki Rolü,
- Determination of Cytosolic Endoplasmic Reticulum and Mitochondrial Free Zinc Levels in Cardiomyocytes by Using Genetically Encoded Zinc Sensitive FRET Sensors,
- TÜRKİYE DİYABET VAKFI DIABETES MELLITUS BİLİMSEL PROJE DESTEK ÖDÜLÜ , 2016
- BÖLÜME EN YÜKSEK NOT İLE GİRİŞ, 2002
- BİLİMSEL ETKİNLİĞE KATILIM DESTEĞİ, 2009
- BİLİMSEL ETKİNLİĞE KATILIM DESTEĞİ, 2008
- FEN FAKÜLTESİ KAPSAMINDA ÜÇÜNCÜLÜKLE MEZUNİYET, 2006
- BİYOLOJİ BÖLÜMÜNDEN BİRİNCİLİKLE MEZUNİYET, 2006
- YÜKSEK LİSANS BURSU, 2006
- BİLİMSEL ETKİNLİĞE KATILIM DESTEĞİ, 2010
- BİLİMSEL ETKİNLİĞE KATILIM DESTEĞİ, 2008
- BİLİMSEL ETKİNLİĞE KATILIM DESTEĞİ, 2009
- BİLİMSEL ETKİNLİĞE KATILIM DESTEĞİ, 2010
- POSTER ÖDÜLÜ, 2013
- BİLİMSEL ETKİNLİĞE KATILIM DESTEĞİ, 2011
- POSTER ÖDÜLÜ, 2016
- BİLİMSEL ETKİNLİĞE KATILIM DESTEĞİ, 2012