Aslı Kutlu completed her undergraduate studies at the Department of Chemical and Biological Engineering at Koç University in 2012. In 2012, she started her Ph.D. studies at the Department of Molecular Biology, Genetics and Bioengineering. Sabancı University under the supervision of Prof. Uğur Sezerman. Her research studies are about protein engineering for industrial applications. After receiving her Ph.D. in 2017, she worked as a post-doctoral fellow at Acıbadem Mehmet Aydınlar University, Department of Medical Statistics and Bioinformatics, School of Medicine, where she joined the Sezerman lab again. During the postdoctoral fellowship, she mainly focused on studying the mechanism of rare diseases through molecular dynamics (MD) studies to elucidate the role of novel mutations. Between February 2019 and August 2020, she worked at Biruni University as an assistant professor. In September 2020, she joined the ISU Department of Molecular Biology and Genetics as a PI in the field of molecular cancer research and rare disease mechanism through experimental and computational approaches.
Araştırma Alanları
- Protein Engineering
- Bioinformatics Analysis
- Modeling and Simulation
- Cancer Biology
- Anticancer Drug Development
- Molecular Genetics
- Contributing to the Functional Classification of Missense Variants in RAG1 Protein from Structural Perspective, 2025
- Fc–FcγRI Complexes: Molecular Dynamics Simulations Shed Light on Ectodomain D3′s Potential Role in IgG Binding, 2024
- TNFRSF13B VARIANTS ACT AS MODIFIERS TO CLINICAL PHENOTYPES IN COMMON VARIABLE IMMUNE DEFICIENCY DISORDERS, 2023
- Repurposing Fc gamma receptor I (FcγRI, CD64) for site-oriented monoclonal antibody capture: A proof-of-concept study for real-time detection of tumor necrosis factor-alpha (TNF -α), 2023
- Identification of key genes and pathways for cholangiocarcinoma using an integrated bioinformatics analysis, 2022
- Discussing the roles of proline and glycine from the perspective of cold adaptation in lipases and cellulases, 2022
- Computational analysis of missense filamin-A variants, including the novel p.Arg484Gln variant of two brothers with periventricular nodular heterotopia., 2022
- Identifying and elucidating the roles of Y198N and Y204F mutations in the PAH enzyme through molecular dynamic simulations, 2021
- Elucidating the roles of naturally occurring silent mutations in Polycystic Ovary Syndrome (PCOS), 2020
- Understanding the impacts of self-shuffling approach on structure and function of shuffled endoglucanase enzyme via MD simulations, 2020
- A possible founder mutation in FZD6 gene in a Turkish family with autosomal recessive nail dysplasia, 2019
- Enhancing Enzymatic Properties of Endoglucanase I Enzyme from Trichoderma Reesei via Swapping from Cellobiohydrolase I Enzyme, 2019